July 20, 2012

Sanofi and Regeneron Launch Comprehensive Phase 3 Clinical Program with LDL Cholesterol-Lowering PCSK9 Antibody

- ODYSSEY, a global program to evaluate SAR236553/REGN727, a potential first-in-class PCSK9 inhibitor, will comprise over ten clinical trials and will include more than 22,000 patients -

 

Sanofi and Regeneron Launch Comprehensive Phase 3 Clinical Program with LDL Cholesterol-Lowering PCSK9 Antibody
- ODYSSEY, a global program to evaluate SAR236553/REGN727, a potential first-in-class PCSK9 inhibitor, will comprise over ten clinical trials and will include more than 22,000 patients -

Paris, France and Tarrytown, N.Y. – July 20, 2012 – Sanofi (EURONEXT: SAN and NYSE: SNY) and Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) announced today that several trials within ODYSSEY, the Phase 3 clinical program of SAR236553/REGN727, have initiated patient enrollment. SAR236553/REGN727 is a potential first-in-class, subcutaneously administered, fullyhuman antibody that lowers low-density lipoprotein (LDL) cholesterol by targeting PCSK9 (proprotein convertase subtilisin/kexin type 9), an enzyme which binds LDL receptors, leading to their accelerated degradation and increased LDL-cholesterol (LDL-C) levels.